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Mucoadhesive buccal film having a dual release carrier system
Mucoadhesive buccal film having a dual release carrier system
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摘要
Mucoadhesive buccal films comprising a statin-hydroxypropyl-beta-cyclodextrin inclusion complex and a statin-loaded mixed micelle composition, wherein the ratio of the mixed micelle composition to the inclusion complex is from 2:0.5 to 2:1.5 are provided. Methods of improving permeation of a statin across mucosal tissue by administering the film to a subject are also provided.
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