EVALUATING THE CYTOTOXIC POTENTIAL OF METHONOLIC LEAF EXTRACT OF ALEO VERA ON MCF-7 BREAST CANCER CELL LINES

摘要

Objective: Breast cancer is the second leading cause of death among cancer pateints. Ayurvedic?system of traditional medicine validated the use of plants as a useful source for occurrence of anticancer compounds. This study was attempted to investigate the in vitro anti-cancer potential of methanolic extract of Aleo vera on breast cancer MCF-7 cell lines. Methods: The methanol extract of Aleo vera was screened for its anti-proliferative effect against MCF-7 (Breast cancer) cell lines seeded on 96 well plates. Results: MCF-7 cells were treated with the extract for 24h and 72h at a range of increasing concentrations (0-500μg/ml) in order to obtain a dose-response graph and IC50 value. The Aleo vera extract showed cytotoxic effect in MCF-7cells with IC 50 of 74.33 μg/ml. Conclusion: The Aleo vera extract showed effective cytotoxic activity in a dose and time dependent manner. Future investigations will be interesting to find an active principle and also better understand its mechanism of action against cancer.