COMBATTING CHALLENGING ASPECTS OF CANCER WITH THIOSEMICARBAZONES

摘要

Cancer claims the second largest number of deaths across the globe every year. With the new addition and discoveries in the therapeutic area, there are also some serious challenges which come into play. These include the emergence of resistance, malignancy, relapses and some life-threatening adverse effects. These challenges further intensify the need to discover better alternatives. Thiosemicarbazones have been explored extensively against many resistant and non-resistant forms of cancer in vitro as well as in vivo. Chelation of iron and copper has been attributed to their activity as anticancer agents, but recent studies have revealed few more complex mechanisms of their action. With different approaches to target different aspects of cancers, they have gained ample attention. Structural variations of these compounds were found to be highly selective in their action.