Diastolic Function of the Left Ventricle Depending on the Degree of Renal Dysfunction in the Background of Treatment

摘要

Background: To study the effect of lisinopril and losartan on the diastolic function of the left ventricle in patients with chronic heart failure (CHF), depending on the degree of renal dysfunction (RD). Materials and methods: A total of 223 patients with I-III FC of CHF were examined, initially and after 6 months. The first group consisted of 118 patients taking lisinopril as part of standard therapy; the second group - 105 - losartan. All patients were distributed depending on the estimated of the glomerular filtration rate (eGFR): 30 < eGFR ≤60 - 67 patients and eGFR > 60 ml / min / 1,73m~(2) -156 patients. Results: The analysis of baseline diastolic function in patients with CHF revealed diastolic dysfunction in 81,8% of patients with CHF, with a predominance of delayed relaxation in 59,3% of patients and an increase in the number of patients with a restrictive type of diastolic dysfunction in patients with III FC of CHF. The dependence between the parameters of the diastolic function - the rate of E and eGFR was revealed. Patients of the first and second groups with I-III FC of CHF after 6 months of treatment had an improvement in diastolic left ventricle function with advantage in patients in the group of losartan with I and III FC of CHF. On the background of treatment in patients with CHF with eGFR≤60 ml/min/1,73 m~(2) there was a significant increase in the rate of E in both groups of patients without statistically significant differences. Conclusion: Patients of the first and second groups with I-III FC of CHF after 6 months of treatment had an improvement in diastolic function left ventricle.