Premature ovarian failure incidence, risk factors and its relation to BMI and infertility

摘要

Background: Premature ovarian failure (POF) is cessation in the normal functioning of the ovaries in women younger than age 40 years. It is estimated to affect1% of women younger than 40 years and 0.1% of those under 30 years. Premature ovarian failure is a common cause of infertility in women. Methods: Patient attending outpatient Department of Obstetrics and Gynecology with age less than 40 years and complaint of menstrual disturbances, symptoms of menopause were enrolled for the study for duration of 1year. This study is planned to calculate the incidence, risk factors, relation to BMI and infertility in patients attending outpatient department at Geetanjali medical college and hospital, Udaipur for all enrolled patient coming with complaints of menstrual disturbances. FSH levels were send for all the patients and those with FSH level more than 20 at day 2/3 for menstruating women and random FSH level for amenorrhea patient more than 20 were classified in to study group and all those women with FSH less than 20 are taken as control group. Results: Present study strongly suggests that simple laboratory test FSH and symptoms of missed and irregularity of menstrual cycle help in early and prompt diagnosis of premature ovarian failure. And early diagnosis helps in avoiding unnecessary medications and helps in improving long term morbidity. Conclusions: Disturbances in menstrual cycle like amenorrhea and infrequent cycles are the symptoms which are associated with premature ovarian failure after ruling out pregnancy and other hormonal and structural causes.