The Correlation of Insulin Resistance with B cell Function, Metabolic, and Hormonal Parameters in Type 2 Diabetic Women Treated with Metformin

摘要

Beta cell dysfunction and insulin resistance are believed to cause persistent hyperglycemia which characterizes type 2 diabetes. Previous study found potential relationship between elevated free testosterone level and an insulin resistance status in hyperprolactinemia women. Treatment with different doses of metformin result in a significant reduction in prolactin level. This study is designed to explore the potential role of metformin in improving β cell function via its effect on ameliorating metabolic and hormonal parameters in type 2 diabetic women by direct or indirect relationship. A 20 middle age newly diagnosed type II diabetes mellitus female patients treated with 1500mg metformin daily for 6 months. Fasting blood glucose, fasting serum insulin, HOMA-IR, HOMA-B, serum prolactin, total and free testosterone were measured. Following three to six months with metformin therapy, significant improvement in glycemic parameters, insulin resistance, β cell function was clear(P<0.05). Similarly for endogenoustotal and free testosterone, and serum prolactin levels were significantly reduced (P<0.05). Fasting serum insulin positively correlated only with serum prolactin after 6 months of metformin therapy (P<0.05). Fasting serum insulin and IR showed negative correlation with free testosterone at the baseline and after metformin therapy (P<0.05). The reduction in serum prolactin and endogenous total and free testosterone following metformin therapy may potentially reduce fasting serum insulin, insulin resistance, and thereby improves β cell function.