THE EFFECT OF MULTI MINERAL?VITAMIN D SUPPLEMENTATION ON PREGNANCY OUTCOMES IN PREGNANT WOMEN AT RISK FOR PRE?ECLAMPSIA

摘要

Background: The objective of this study was to determine the favorable effects of multi mineral ? Vitamin D supplementation on pregnancy outcomes among women at risk for pre ? eclampsia.Methods: This randomized double ? blind controlled clinical trial was conducted among 46 women at risk for pre ? eclampsia at 27 weeks’ gestation with positive roll ? over test. Pregnant women were randomly assigned to receive either the multi mineral ? Vitamin D supplements (n = 23) or the placebo (n = 23) for 9 ? week. Multi mineral ? Vitamin D supplements were containing 800 mg calcium, 200 mg magnesium, 8 mg zinc, and 400 IU Vitamin D3. Fasting blood samples were taken at baseline and after 9 ? week intervention to measure related factors. Newborn’s outcomes were determined.Results: Although no significant difference was seen in newborn’s weight and head circumference between the two groups, mean newborns’ length (51.3 ± 1.7 vs. 50.3 ± 1.2 cm, P = 0.03) was significantly higher in multi mineral ? Vitamin D group than that in the placebo group. Compared to the placebo, consumption of multi mineral ? Vitamin D supplements resulted in increased levels of serum calcium (+0.19 vs. -0.08 mg/dL, P = 0.03), magnesium (+0.15 vs. -0.08 mg/dL, P = 0.03), zinc (+8.25 vs. ?21.38 mg/dL, P = 0.001) and Vitamin D (+3.79 vs. -1.37 ng/ml, P = 0.01). In addition, taking multi mineral ? Vitamin D supplements favorably influenced systolic blood pressure (SBP) (-1.08 vs. 6.08 mmHg, P = 0.001) and diastolic blood pressure (DBP) (-0.44 vs. 3.05 mmHg, P = 0.02).Conclusions: Multi mineral ? Vitamin D supplementation for 9 ? week in pregnant women at risk for pre ? eclampsia resulted in increased newborn’s length, increased circulating levels of maternal serum calcium, magnesium, zinc and Vitamin D, and led to decreased maternal SBP and DBP.