MINIATURIZED IC BIOSENSORS ON A SINGLE CHIP FOR BIOLOGICAL/BIOMEDICAL APPLICATIONS

摘要

Hybrid biosensors based CMOS Microtechnology and Nanotechnology is high-demand to meet the needs of human’shealth care and environmental concerns. The sky is limit for R&D biomedical and biological transducers. Heretofore, thesemiconductor industry has miniaturized IC biosensors individually, whereas this work will present a single die has set ofbiosensors implemented within it, which leads to a new generation of multidisciplinary biosensors named as multi-labs-on-a-singlechip (MLoC). The invented system will be the most promising and superior transducer in trends of health care human services, asthere are a lot of patients in hospitals are contaminated with antibiotic-resistant bacteria, resulting in lavished a lot of money ontothe health-care system. Early detection is critical for improved patient care and can help in minimizing the risk of crosscontamination between patients. The presented system is introducing different techniques based on CMOS/MEMS technologybatch process for early detecting tumors. In addition, the MLoC system will function accurately in biological fields such asdetecting pathogen bacterial cell at low concentration levels. The multidisciplinary biosensors miniaturizes four transducers eachone is based on a different biosensors approaches; these approaches are based on optical CMOS technology, charge basedcapacitance measurements (CBCM), electrochemical impedance spectroscopy (EIS) and CMOS microcoils incorporating withinterdigitated microelectrode array (IDMA). The fabricated chip has been successfully tested and represented a viable solution forportable, sensitive and rapid detection of pathogens bacterial.