Prescribing Pattern of Medications that induce Extra Pyramidal Symptoms and Weight Gain in Psychotic Patients

摘要

The objective of the study is to assess the prescribing pattern of drugs that induces Extra Pyramidal Symptoms (EPS) and weight gainin psychotic patients under treatment. A descriptive-observational study was carried out in the psychiatry department of MVJmedical college and research hospital for a period of six months. A total of 105 in-patients were enrolled into the study afterfulfilling the study criteria and obtaining informed consent. The prescription pattern was analyzed and the various medicationrelated problems were identified. The obtained data were analyzed descriptively and statistically. A total of 105 psychotic patientswere enrolled into the study. On analyzing the prescription, most of the patients were prescribed with more than 3 drugs. Majorityof the patients were prescribed with 3 psychotropic drug (43.80%) in which antipsychotics were prescribed to all the patient. Themost commonly given combination of psychotropic drugs are antipsychotic- anti anxiety (42.85%). 70.48% of the study populationwas on antipsychotic mono therapy. Majority of the patients were taking only atypical antipsychotics (83.80%). Prescribing error(32.38%) was the commonly seen medication error followed by dispensing error. There were a total of 353 interactions identified,out of which 61 were major interactions. Our study showed that extra pyramidal symptoms and weight gain are still serious sideeffects of the treatment of various psychotic disorders. This is confounded by various factors like medication error, drug-druginteraction, poly pharmacy. The clinicians can be advised to compare the benefit risk ratio based on the needs of the individualpatients and thereby choosing an appropriate drug with optimum therapeutic efficacy and low toxic effect. The patients should beadvised to control their diet and to involve in physical activities when under treatment to control unnecessary weight gain.