Solubility of a drug is a major concern for its therapeutic action and becomes more prominent when the drug is lipophilic in nature. Zaltoprofen is a novel non–steroidal anti-inflammatory class of drug, but problem associated with is the poor solubility in biological fluids. The present study was performed to investigate the effect of different stabilizers (in single or in combination form) on solubility, particle size, zeta potential, dissolution rate and stability of nano suspension of water insoluble drug Zaltoprofen. Nanosuspension is prepared by using wet mill, high pressure homogenizer, precipitation, and melt emulsification method. In the present work nano suspension was prepared by solvent/anti solvent precipitation method using different steric stabilizers like pluronic F-68, F-127and electrostatic stabilizer like sodium lauryl sulphate. The optimized formulation showed an average particle size 179nm and a zeta potential of -28.4mV. The rate of dissolution of the optimized nano suspension was enhanced (82% in 45min), relative to bulk drug of Zaltoprofen (22% in 45min), mainly due to the formation of nanosized particles. The obtained results showed that nano suspension prepared in combination form of stabilizers like pluronic F-68 and sodium lauryl sulphate has improved dissolution rate. The increase in in-vitro dissolution rate may favourably affect bioavailability and improve safety for the patient by decreasing gastric irritancy. Stability study revealed that nano suspension was more stable at room and refrigerator condition with no significant change in particle size distribution. The results indicate that the combination of stabilizers may contribute in enhancement of the solubility, dissolution rate, and stability.
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