Novel drug delivery system for the treatment of periodontitis was developed for site‐specific delivery of Minocycline hydrochloride which has excellent activity against anaerobic microorganisms. Minocycline films were prepared by solvent casting technique using ethyl cellulose, HPMC K4M and EudragitRL100 as copolymer in chloroform: ethanol (1:1) solvent with di-butyl phthalate and PEG 400 as plasticizers. FT‐IR and UV spectroscopic methods revealed no interaction between Minocycline hydrochloride and polymers. The films were evaluated for their thickness uniformity, folding endurance, weight uniformity content uniformity, surface pH, and in vitro antibacterial activity. In vitro release from periodontal films was fit to different equations and kinetic models like zero order, first‐order equations and Hixson‐Crowell, Higuchi models and korsmeyer peppas model to reveal drug release kinetics. The x-ray diffraction studies of the drug and the film showed that the classical peaks of the drug were depressed in physical mixture and more in the formulation. SEM studies indicated complete embedding of the drug in the film. The Formulation A6 released 91.37 % of drug at the end of seventh day and was considered as best formulation. The optimized formulation showed good antibacterial properties against S.aureus (MMTC3160) and E.coli (MMTC448). Ageing studies shows that the drug remained intact and stable in the periodontal films during storage. A short‐term stability study shows that drug content decreased in various films and was ranging from 0.9% to 3.41%.
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