Hesperidin Exerts the Gestational Diabetes Mellitus via AGEs-RAGE Signalling Pathway

摘要

Background and Objective: Gestational diabetes mellitus (GDM) are known as the increased risk of postpartum type 2 diabetes. It is believed that the efficient maternal glycemic control of GDM could not decrease the neonatal morbidity from serious complications. Thus, this study was aimed to investigate the protective effect of hesperidin against streptozotocin (STZ) induced gestational diabetes mellitus (GDM) rat models and its possible mechanism. Materials and Methods: The STZ was used for the induction of diabetes mellitus for the pregnant rats and received the hesperidin to 19 days. On the 19th days (pregnant rats), the blood samples and fetal rats of all group rats were collected, weighted the fetal rats and placental was estimated. Serum advanced glycation end products (AGEs) was estimated in the heart and brain of pregnant rats at regular interval. The mRNA expression of NOX2, MCP-1, RAGE, p65, VEGF, VCAM-1 and RAGE were estimated in the placenta. Results: Dose-dependent treatment of hesperidin significantly (pConclusion: Hesperidin showed the potential effect on fetal development in pregnant rats with gestational diabetes mellitus via AGEs-RAGE signalling pathway.