Potential Effective Lipid-Lowering Medicine - Betulonic Acid Mild Selective Synthesis and Pharmacological Activity”

摘要

Hyperglycemia induced oxidative stress has been proposed as a cause of many complications in diabetes including cardiac dysfunction. The present study depicts the therapeutic effect of Cassia alata leaf aqueous extract on oxidative stress in aorta as well as heart of streptozotoc in hyperglycemic rats. Two days after diabetes induction, Cassia alata leaf aqueous extract was administered orally for 20 days (200mg/kg rat’s weight). In the aorta and heart of hyperglycemic rats there was a significant increase in lipid peroxidation, decreased in total antioxidant activity (DPPH free radical scavenging activity) as well as decrease in antioxidant catalase activity. The administration of Cassia alata leaf aqueous extract to hyperglycemic rats has reduced lipid peroxidation (MDA levels), increased in total antioxidant activity (DPPH free radical scavenging activity) and antioxidant catalase activity as well as reduced in the blood glucose level. Cassia alata leaf aqueous extract provide a competent antioxidative mechanism to attack against the oxidative stress in the aorta and heart of hyperglycemic rats. This study suggests that Cassia alata may be a useful therapeutic alternative in the reversal of oxidative stress induced cardiac dysfunction in hyperglycemic condition as well as capable to act as antidiabetic agent.