Effect of Fraction 3 of portulaca oleracea onHaematological and Plasma Biochemical Parameters in Male Albino Rats

摘要

The effect of oral administration of chromatographic fraction 3 of Portulaca oleracea at doses of 1 mg/kg BW, 2 mg/kg BW and 3 mg/kg BW on haematological and plasma biochemical parameters of albino rats were investigated. The fraction was administered on daily basis for 30 days and blood samples were collected for analyses. Treatment of rats with 3 mg/kg BW of fraction 3 caused significant (p<0.05) decrease in the PCV and RBC values relative to their respective controls, while treatment of rats with 3 mg/kg BW of fraction 3 caused significant (p<0.05) increases in TWBC and platelet counts relative to their respective controls. Treatment of rats with 1 mg/kg BW, 2 mg/kg BW and 3 mg/kg of fraction 3 resulted in significant (p<0.05) increases in the albumin level as well as AST and ALT activities relative to their respective controls. These findings on haematological and plasma biochemical parameters suggest that the possible changes in blood chemistry of the treated rats were due to chromatographic fraction 3 of Portulaca oleracea.