Effect of the Reference Imidazoline Drugs, Clonidine and Rilmenidine, on Rat Eye Pupil Size Confirms the Decisive Role of α<SUB>2</SUB>-Adrenoceptors on Mydriasis

Joanna Raczak-Gutknecht; Teresa Frackowiak; Antoni Nasal; Joanna Rietz; Maja Paszek; Magdalena Buszewska-Forajta; Roman Kaliszan

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Effect of the Reference Imidazoline Drugs, Clonidine and Rilmenidine, on Rat Eye Pupil Size Confirms the Decisive Role of α₂-Adrenoceptors on Mydriasis

机译：参考咪唑啉药物可乐定和利美替尼对大鼠眼瞳孔大小的影响证实了α_{2 -肾上腺素能受体对瞳孔散大的决定性作用}

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The in vivo rat mydriasis model provides more information on ligand-receptor interactions than in vitro studies. It allows assessment which receptors (α₂-adrenergic or imidazoline) participate in mydriatic effect produced by imidazoline co

机译：与体外研究相比，体内大鼠瞳孔散大模型提供了更多有关配体-受体相互作用的信息。它可以评估哪些受体（α_{2 -肾上腺素或咪唑啉）参与由咪唑啉合剂产生的散瞳作用}

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《International Journal of Pharmacology》 |2014年第8期|共9页
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Joanna Raczak-Gutknecht; Teresa Frackowiak; Antoni Nasal; Joanna Rietz; Maja Paszek; Magdalena Buszewska-Forajta; Roman Kaliszan;
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中图分类药学;
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1. Rat clonidine mydriasis model: imidazoline receptors are not involved. [J] . Yu Y, Koss MC Autonomic neuroscience: basic & clinical . 2005,第1期

机译：大鼠可乐定散瞳模型：不涉及咪唑啉受体。
2. Are Alpha-2D Adrenoceptor Subtypes Involved in Rat Mydriasis Evoked by New Imidazoline Derivatives: Marsanidine and 7-Methylmarsanidine? [J] . Joanna Raczak-Gutknecht, Teresa Fr?ckowiak, Antoni Nasal, Dose-response . 2017,第2期

机译：新的咪唑啉衍生物：Marsanidine和7-Methylmarsanidine引起的大鼠瞳孔散大是否涉及Alpha-2D肾上腺素受体亚型？
3. Topically applied clonidine protects the rat retina from ischaemia/reperfusion by stimulating alpha(2)-adrenoceptors and not by an action on imidazoline receptors. [J] . Chao HM, Osborne NN Brain research . 2001,第1期

机译：局部应用可乐定可通过刺激α（2）-肾上腺素受体而不是通过对咪唑啉受体的作用来保护大鼠视网膜免于缺血/再灌注。
4. Role of Microscopy as the Reference Method for Particle Size Analysis in Drug Development [C] . L.M. DiMemmo, M. Hubert, B. Sarsfield, International Metallographic Society Annual meeting;Microscopy Society of America Annual Meeting;Microanalysis Society Annual meeting . 2011

机译：显微镜作为药物开发中粒度分析的参考方法的作用
5. Are Alpha-2D Adrenoceptor Subtypes Involved in Rat Mydriasis Evoked by New Imidazoline Derivatives: Marsanidine and 7-Methylmarsanidine? [O] . Joanna Raczak-Gutknecht, Teresa Frąckowiak, Antoni Nasal, 2017

机译：新的咪唑啉衍生物：Marsanidine和7-Methylmarsanidine引起的大鼠瞳孔散大是否涉及Alpha-2D肾上腺素受体亚型？
6. Рhotopic Negative Response for Testing the Function of Inner Retina: Registration Requirements and Comparison in the Eyes with Natural Pupil Width and in Conditions of Drug Mydriasis [O] . V. I. Kotelin, M. O. Kirillova, M. V. Zueva, 2020

机译：检测内视网膜功能的功能响应：注册要求和天然瞳孔宽度和药物瞳孔条件的眼睛比较

Effect of the Reference Imidazoline Drugs, Clonidine and Rilmenidine, on Rat Eye Pupil Size Confirms the Decisive Role of α2-Adrenoceptors on Mydriasis

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Effect of the Reference Imidazoline Drugs, Clonidine and Rilmenidine, on Rat Eye Pupil Size Confirms the Decisive Role of α₂-Adrenoceptors on Mydriasis