Integrated Therapy of Diet and Ayurvedic Drug May Be a Safer Choice in the Prevention of Oxidative Stress-Induced Diabetes Mellitus”

摘要

Herbal drug therapy and restricted diet (RD) are known to improve diabetes mellitus (DM) and its associated problems. Here, we aimed to examine the importance of RD alone or in combination with a polyherbal drug, Diabecon in the prevention of alloxan induced DM. For this young diabetic rats were either kept on 50% RD and/or treated with Diabecon (2 gm /Kg body weight) for two months and then different indices were estimated. Finding revealed a significant increase in serum glucose, G6Pase, atherogenic index (AI), tissue oxidative stress with decrease in insulin and hepatic glycogen content in diabetic rats. While rats kept on either therapy exhibited significant improvement in most of the parameters, best protective effects were observed in animals which received the drug and were also under RD therapy. In conclusion, RD and polyherbal drug therapy cured the remedy and exhibited additive protection against oxidative stress.