The demand for fast disintegrating tablets has been growing, during the last decade especially for geriatric and pediatric patients because of swallowing difficulties. Atenolol a selective β – Adrenergic Blocker is widely used to reduce elevated blood pressure in hypertensive patients. Fast disintegrating tablets of Atenolol were prepared by superdisintegrant addition method. The tablets were prepared by direct compression method using super disintegrants like crospovidone, croscarmellose, sodium starch glycolate. The blend was examined for various pre compression parameters. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio, in vitro dispersion time and in vitro drug release pattern (in pH 6.8 phosphate buffer). Among all the formulations, the formulation prepared by using 8% w/w of croscarmellose (ACC5) emerged as the overall best formulation, based on the in vitro dispersion time, wetting time, water absorption ratio and in-vitro dissolution profile compared to control tablet formulation. Short-term stability studies on the formulations indicated that there are no significant changes in drug content and in vitro dispersion time.
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