HbA1C as a Predictor of Left Ventricular Diastolic Dysfunction (LVDD) in Type 2 Diabetic Patients

摘要

Background: Diabetes mellitus is a worldwide health problem, affecting millions of people in both developed and developing countries. Cardiovascular diseases like congestive heart failure, coronary artery disease, myocardial infarction which are commonly associated with diabetes are the leading cause of mortality in diabetic patients. Diabetes, itself can lead to the development of heart failure (HFnEF) referred to as diabetic cardiomyopathy. Objective: To assess the correlation of HBA1C levels with left ventricular diastolic dysfunction in newly diagnosed Type 2 diabetic patients. Materials and Methods: The present study was conducted in R L Jalappa hospital, Kolar, Karnataka. All the newly detected type 2 diabetic patients (detected within one month) presented to the OPD and admitted to wards of department of General Medicine, fulfilling the inclusion criteria were included in the study. Sample size of 100 is obtained by the formula n = 4pq/d~(2) with 95% confidence level, 10% error and 5% alpha error. It was a observational prospective (cross sectional) type of study. Results: 56 out of 100 participants (56%) were males and 44 (44%) were females. Age of the patients was between 42 to 58 yrs, with mean age being 52 years. Mean age of subjects with LVDD was 52.68± 5.69 years and that of population without LVDD was 46.38 ±5.15 years. The mean HbA1C of subjects with LVDD was 7.95 ±1.09 and of subjects without LVDD was 7.21 ± 1.22. HbA1c level is positively associated with the incidence of LVDD in diabetic population as mean HbA1C of population. Conclusion: Our study showed that HbA1c is a reliable predictor of LVDD in the newly diagnosed cases of type 2 diabetes mellitus.