Cardiac Manifestations in Overt and Subclinical Hypothyroidism Subjects in a Tertiary Care Centre

摘要

Background: Thyroid hormones are very vital for the normal functioning of heart. Cardiovascular manifestations are frequent findings hypothyroidism. Hypothyroidism and can produce changes in cardiac contractility, myocardial oxygen consumption, cardiac output, blood pressure and systemic vascular resistance. Most cardiac abnormalities return to normal once a euthyroid state has been achieved. Methods: Cross sectional study on 100 cases of hypothyroidism was carried out in a tertiary care centre. Structured questionnaire was to collect information from subjects with respect to history, clinical examination and investigations. ECGs and 2D ECHO was done to find the cardiac changes and diastolic dysfunction. Data was analyzed using SPSS 22 version software. Chi-square was used as test of significance. Pearson correlation was done to find the correlation between two quantitative variables. p value 50 years (34%). Females constituted 72% and males were 28%. Commonest symptom on presentation was Dyspnea (60%). 82% of subjects had Overt Hypothyroidism and 18% had Subclinical Hypothyroidism. On ECG, 30% had Bradycardia, 24% had abnormal LVC, 18% had ST T changes, 8% had long QT, 6% had RBBB, 4% had RAD, prolonged PR and LAD respectively and 2% had LBBB. On Echo 52% had pericardial effusion, 28% had LV Hypokinesia and 20% had out of 40 subjects with Overt Hypothyroidism, 45% had diastolic dysfunction and out of 10 subjects with Sub Clinical Hypothyroidism, 10% had diastolic dysfunction. Significant Positive correlation was observed between T3 and Ejection Fraction and Significant Negative correlation was observed between TSH and Ejection Fraction. Conclusion: Study concludes that there was significant association of hypothyroidism with cardiac diseases especially those of diastolic dysfunction and pericardial effusion. The findings suggest the importance of early detection and effective treatment of cardiac abnormalities in patients affected by thyroid disorders.