Childhood Acute Lymphoblastic Leukemia with Near-Tetraplody And t(12; 21) (p13;q22) Translocation: A Case Report

Mutlu KARKUCAK; Tahsin YAKUT; Birol BAYTAN; Tuna GULTEN; A. Meral GUNES

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Childhood Acute Lymphoblastic Leukemia with Near-Tetraplody And t(12; 21) (p13;q22) Translocation: A Case Report

机译：儿童急性淋巴细胞白血病近四联症和t（12; 21）（p13; q22）易位：一例报告

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Fluroscent in situ hybridization analysis indicated presence of t(12;21)(p13;q22) translocation and near-tetraploidy in a case who 11-year-old boy and diagnosed with B precursor acute lymphoblastic leukemia (ALL). Although, some studies suggest good prognostic effect of translocation t(12;21) (p13;q22), there were very little data regarding the prognostic effect of Near- tetraploidy. Here we discussed the prognostic relevance of both t(12;21)(p13;q22) translocation and near tetraplody in Pre-B ALL.

机译：荧光原位杂交分析表明存在t（12; 21）（p13; q22）易位和接近四倍体的情况下，这名11岁男孩被诊断为B型前体急性淋巴细胞白血病（ALL）。尽管一些研究表明易位t（12; 21）（p13; q22）的预后良好，但关于四倍体的预后效果的数据很少。在这里，我们讨论了Pre-B ALL中t（12; 21）（p13; q22）易位和接近四倍体的预后相关性。

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《International Journal of Hematology and Oncology》 |2018年第2期|共4页
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Mutlu KARKUCAK; Tahsin YAKUT; Birol BAYTAN; Tuna GULTEN; A. Meral GUNES;
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入库时间 2022-08-18 09:09:57

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1. Childhood Acute Lymphoblastic Leukemia with Near-Tetraplody And t(12; 21) (p13;q22) Translocation: A Case Report [J] . A. Meral GUNES, Birol BAYTAN, Mutlu KARKUCAK, International Journal of Hematology and Oncology . 2016,第4期

机译：儿童急性淋巴细胞白血病近四联症和t（12; 21）（p13; q22）易位：一例报告
2. Childhood Acute Lymphoblastic Leukemia with Near-Tetraplody And t(12; 21) (p13;q22) Translocation: A Case Report [J] . A. Meral GUNES, Birol BAYTAN, Mutlu KARKUCAK, International Journal of Hematology and Oncology . 2016,第4期

机译：儿童急性淋巴细胞白血病近四联症和t（12; 21）（p13; q22）易位：一例报告
3. Childhood B-cell progenitor acute lymphoblastic leukemia presenting a three-way t(11;12;21)(q14;p13;q22) with a RUNX1 gene signal on chromosome 11 [J] . Ney-GarciaD.R., LiehrT., BhattS., International journal of hematology . 2012,第1期

机译：儿童B细胞祖细胞急性淋巴细胞白血病在11号染色体上呈三向t（11; 12; 21）（q14; p13; q22）表达RUNX1基因信号
4. Machine Learning Approach to Predict the Survival Time of Childhood Acute Lymphoblastic Leukemia Patients [C] . Rangana Jayashanka, C.R. Wijesinghe, A.R. Weerasinghe, International Conference on Advances in ICT for Emerging Regions . 2018

机译：机器学习方法预测儿童急性淋巴细胞白血病患者的生存时间
5. The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 and BHLHB2 genes. [D] . Wang, Junjie. 2003

机译：与T细胞急性淋巴细胞白血病相关的t（14; 21）（q11.2; q22）染色体易位激活了BHLHB1和BHLHB2基因。
6. Adult B lymphoblastic leukaemia/lymphoma with hypodiploidy (-9) and a novel chromosomal translocation t(7;12)(q22;p13) presenting with severe eosinophilia – case report and review of literature [O] . Farhat Abbas Bhatti, Iftikhar Hussain, Muhammad Zafar Ali 2009

机译：成人B淋巴细胞白血病/淋巴瘤伴二倍体（-9）和新型染色体易位t（7; 12）（q22; p13）表现为严重嗜酸性粒细胞增多症-病例报告和文献复习
7. Prevalência em nosso meio da translocação (12;21)(p13;q22) em leucemia linfoblástica aguda na infância, identificada através de hibridização in situ fluorescente com sondas de DNA para o rearranjo TEL/AML1 Prevalence in Brazil of the (12;21)(p13;q22) translocation in childhood acute lymphoblastic leukemia identified by in situ hybridization with fluorescent DNA probes for the TEL/AML1 rearrangement [O] . Paulo R. G. Zen 2009

机译：通过与TEL / AML1重排的DNA探针进行荧光原位杂交，确定了儿童急性淋巴细胞白血病在我们易位（12; 21）（p13; q22）中的患病率（12; 21）（p13; q22）通过与TEL / AML1重排的荧光DNA探针原位杂交鉴定儿童急性淋巴细胞白血病易位

Childhood Acute Lymphoblastic Leukemia with Near-Tetraplody And t(12; 21) (p13;q22) Translocation: A Case Report

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