Influence of Mild Hyperglycamia on Physical Function, Mood & Cognition after Acute Ischaemic Stroke

摘要

Hyperglycaemia has been linked to increased mortality and poorer physical outcomes after ischaemic stroke, but effects on mood and cognition after ischaemic stroke are less certain. We studied a prospective cohort of people presenting to two teaching hospitals in Australia within 24 hours of an ischaemic stroke to determine the relationship between hyperglycaemia in the first 48 hours after presentation and physical function, mood and cognition three months later. Eighty-six patients with known diabetes or a glucose greater than 7mmol/l at presentation were included. Their mean admission glucose was 6.85mmol/l. The major determinants of physical function, mood and cognition at 3 months were age, gender, atrial fibrillation (AF), and baseline NIH score. Hyperglycaemia was only significantly associated with quality of life, one of the 2 components in the mood domain, and this remained significant in the multiple regression model. Mild hyperglycaemia in the first 48 hours of acute ischaemic stroke is potentially associated with worse quality of life at 3 month post-stroke. The major determinants of physical, cognitive & emotional outcomes remain age, gender, baseline NIH and presence of atrial fibrillation.