COMPARISON OF METABOLIC AND HORMONAL PROFILES OF WOMEN WITH AND WITHOUT PREMENSTRUAL SYNDROME: A COMMUNITY BASED CROSS-SECTIONAL STUDY

摘要

Background: Premenstrual syndrome (PMS) is reported by up to 85% of women of reproductive age. Although several studies have focused on the hormone and lipid profiles of females with PMS, the results are controversial.Objectives: This study was designed to investigate the association of hormonal and metabolic factors with PMS among Iranian women of reproductive age.Materials and Methods: This study was a community based cross-sectional study. Anthropometric measurements, biochemical parameters, and metabolic disorders were compared between 354 women with PMS and 302 healthy controls selected from among 1126womenof reproductive age who participated in the Iranian PCOS prevalence study. P valuesResults: Prolactin (PRL) and triglycerides (TG) were significantly elevated inwomenwith PMS, whereas their testosterone (TES), high density lipoprotein (HDL) and 17-hydroxyprogesterone (17-OHP) levels were significantly less than they were in women without the syndrome (PConclusions: There was a significant association between PMS scores and the prevalence of metabolic syndrome. Further studies are needed to confirm and validate the relationships between lipid profile abnormalities and metabolic disorders with PMS.