IMPACT OF PLASMA GLUCOSE LEVEL AT THE TIME OF FLUOROD EOXYGLUCOSE ADMINISTRATION ON THE ACCURACY OF FDG-PET/CT IN THE DIAGNOSIS OF PANCREATIC LESIONS

摘要

Background: High fasting plasma glucose (FPG) levels before fluorodeoxyglucose (FDG) administration for positron emission tomography/computed tomography (PET/CT) might affect the accuracy of 18-fluoro-deoxy-glucose-positron emission tomography-computed tomography (FDG-PET/CT) in diagnosis of pancreatic lesions. Current guidelines require FPG levels ofObjectives: The aim of this study was to evaluate the effect of FPG levels ofPatients and Methods: In this retrospective study, 161 patients who had FDG-PET/CT for initial diagnosis of pancreatic lesions were included. Fasting plasma glucose levels before FDG administration were recorded. Accuracy of FDG-PET/CT in diagnosis of pancreatic lesions was compared between patients who were normoglycemic (FPGResults: Thirty-four patients were hyperglycemic and 127 normoglycemic. Sensitivity, specificity, positive predictive value and negative predictive value of FDG-PET/CT were 90%, 88%, 87% and 91% in normoglycemic and 82%, 92%, 95% and 73% in hyperglycemic patients, respectively. Overall, the accuracy was higher in normoglycemic than hyperglycemic patients (89% vs.85%).Conclusions: Accuracy of FDG-PET/CT for primary diagnosis of pancreatic lesions is higher in patients with FPG levels