Electrochemical Sensor for Morphine Based on Gold Nanoparticles/ Ferrocene Carboxylic Acid/Poly (3,4-Ethylene-Dioxythiophene) Composite

摘要

An electrochemical sensors were prepared from different mediators namely ferrocene carboxylic acid(FC1), ferrocene (FC2) and cobaltcene (CC) sandwiched between two layers of poly (3,4-ethylene- dioxythiophene) PEDOT and gold nanoparticles (PEDOT/Mediator/Aunano). The performance of themediator in these different composites was evaluated for the electrocatalytic oxidation of morphine(MO). The results showed that FC1 mediator possesses higher rate for electron transfer and enhancedelectrocatalytic activity due to the inclusion of the ferrocenium ion and the polar substitutedOOHgroup in the conducting polymer matrix which increases the electronic conduction of the film.Excellent performance of (PEDOT/FC1/ Aunano) modified electrode with low detection limit of 21-1 -1 nmol L in the linear dynamic range 5-300 mol L for the determination of MO in human urinesamples with satisfying recovery results was obtained. Furthermore, the PEDOT/FC1/Aunano compositewas successfully used for simultaneous determination of tertiary mixture of morphine, ascorbic acid(AA) and uric acid (UA) and binary mixtures of morphine/ascorbic acid (AA) andmorphine/dopamine.