A Voltammetric Sensor for Determination of Methyldopa in the Presence of Hydrochlorothiazide Using Fe:Co Nanoalloy Modified Carbon Paste Electrode

摘要

In this research the electrochemistry of methyldopa (MDOP) was studied by electrochemical methodsat a carbon paste electrode modified by Fe:Co nano-alloy (Fe:Co/NL/CPE). For this goal we describesynthesis of Fe:Co/NL using ball mill method and then characterize with different methods such asscanning electron microscopy (SEM) and X-ray diffraction (XRD) in the first step. The oxidationpeak potential of the MDOP at a surface of Fe:Co/NL/CPE appeared at 480 mV that was about 100mV lower than the oxidation peak potential at the surface of the unmodified carbon paste electrode(CPE) under similar condition. Result shows for the mixture containing MDOP andhydrochlorothiazide (HCTZ), the peaks potential well separated from each other. Under the optimizedconditions, the oxidation peak current of MDOP showed linear dynamic range (in 0.0600 M) witha detection limit of 0.03 M, using square wave voltammetry (SWV) method. The proposed sensorwas successfully applied for the determination of MDOP in real samples such as tablet, serum andurine.