An Efficient Electrochemical Sensor Based on Ag Nanoparticle Decorated MnO₂/reduced Graphene Oxide Ternary Nanocomposite for Detection of Acetaminophen in Human Urine Sample

摘要

In this study, Ag/MnO2@RGO ternary nanocomposite based electrochemical sensor was found to be thebest for electrochemical detection of acetaminophen (ACTP). In which, reduced graphene oxide (RGO)sheets decorated with MnO2 nanoclusters and silver nanoparticles (Ag NPs) by in situ growth of MnO2on graphene oxide (GO) sheets followed by co-reduction of Ag+ and GO. The Ag/MnO2@RGO ternarynanocomposite possesses tremendous superiority in the ACTP sensing is mainly due to the large surfacearea and numerous electroactive sites. The structural and morphological characteristics of the assynthesized nanomaterial were examined by XRD, FTIR, FE-SEM, HR-TEM, EDX. Theelectrochemical characteristics and catalytic behavior of the fabricated Ag/MnO2@RGO ternarynanocomposite modified screen-printed carbon electrode for the determination of ACTP weredemonstrated using electrochemical impedance spectroscopy, cyclic voltammetry, and differential pulsevoltammetry. The results establish that the developed ACTP sensor exhibit a low detection limit of0.0122 μM, the excellent linear response of 0.02-1810 μM with a good sensitivity of 4.144 μA μM?1cm?2. The practicability of the sensor was investigated in the real sample of acetaminophen tablet andhuman urine sample.