Transdermal Microneedle Array-based Sensor for Real Time Continuous Glucose Monitoring

摘要

We fabricated a low cost, low power consuming and easy to use continuous glucose monitoringsystem in this study. The transdermal sensor consists of an electrochemical sensing unit, a signal - processing unit and a power supply unit. The electrochemical sensing unit comprises an array ofmicroneedle. The transdermal sensor is minimally invasive which can pierce the upper layer of theskin. Glucose Oxidase (GOx) was immobilized on the Au microneedle surface by forming self- assembled monolayer with 3-Mercaptopropionic acid (MPA). The GOx immobilized microneedlewill be used as a subcutaneous glucose sensor to detect the glucose levels in interstitial fluid (ISF).The cyclic voltammetric studies and the transdermal sensing unit developed in this study were able-1 -1 to detect glucose with linear range of 30 mg dL to 400 mg dL . The results showed that theprepared sensor can be used to sense glucose in subcutaneous tissues and are applicable for real - time continuous glucose monitoring system.