Determination of Midazolam by Potentiometric PVC membrane and MWCNTs based Carbon Paste Sensors

摘要

PVC membrane and nano-composite carbon paste potentiometric sensors were made for determinationof midazolam in pharmaceutical formulations. The electrodes respond based on ion-exchangemechanism. The ion-pair used as a sensing element in PVC membrane and carbon paste compositionswas synthesized by interaction of midazolam and tetraphenyl borate. The best PVC membrane sensorresponse was obtained by a membrane composition of 30% PVC, 65% DBP, and 5% ion-pair. Carbonpaste electrode was then designed to have an electrode with the better mechanical resistance. The bestelectrode was composed of 20% ion-pair, 20% paraffin oil, 5% MWCNTs and 55% graphite. Theproposed method was successfully applied in determination of Midazolam in the pharmaceuticalformulations.