Titanium Implant Surface Modification in Physiological Serum Containing New Mixed Inhibitor Based on Poly(vinyl) Alcohol/Silver Nanoparticles/Epirubicin

摘要

The titanium behaviour in physiological serum blank (PS) and containing silver nanoparticles (nAg)and polyvinyl alcohol (PVA) in the absence and presence of epirubicin cytostatic (EPR) was studiedby potentiodynamic polarization and electrochemical impedance/admittance spectroscopy. Theseshowed that the electrochemical parameters classically ranged, meaning that the addition of nAg/PVAand epirubicin in physiological serum leads to corrosion current density decline and polarizationresistance increase while the conductance is diminished. The induced modifications on titaniumsurface were highlighted by optical microscopy and atomic force microscopy (AFM) which displayedthe specific coating adsorbed on titanium surface. Consequently, nAg/PVA improves the epirubicineffect on titanium surface. Prior to the measurements above mentioned, the interactions between nAgand PVA were studied, showing the nAg/PVA composite formation. Also, the interactions between Clions, epirubicin and nAg were discussed, in order to better understand the influence of nAg/PVAcomposite on the epirubicin protective performance on the titanium surface.