Electrochemical Behaviour of Doxorubicin Encapsulated in Apoferritin

摘要

A voltammetric detection of doxorubicin and encapsulated doxorubicin in apoferritin structure at acarbon paste electrode is the main aim of this study. The samples were measured by differential pulsevoltammetry in phosphate buffer (pH 5.5). Complex apoferritin-doxorubicin can be formed by渙pening漜losingdue to changing of pH value. The pH value of electrolyte was decreased andsample of encapsulated doxorubicin was done by adding of hydrochloric acid. We optimized theexperimental conditions as time of accumulation and deposition potential to obtain detection limit forencapsulated doxorubicin of 1.0 g/ml of doxorubicin.