A Novel Electrochemical Method for Sensitive Detection of Anticancer Drug Picoplatin with Graphene Multi-walled Carbon Nanotubes Modified Glassy Carbon Electrode

摘要

In this paper, graphene dispersed multi-walled carbon nanotubes composite modified glassy carbonelectrode (GR-MWNTs/GCE) was prepared and the GR-MWNTs/GCE was employed for theelectrochemical determination of anticancer drug picoplatin. A pair of well-defined redox peak of-1 picoplatin was observed at the GR-MWNTs/GCE in 0.05 mol L KCl solution (pH 7.4) and electrodeprocess is adsorption-controlled. The result indicates that the GR-MWNTs composite materials caneffectively improve the sensibility and performance of the electrode for picoplatin. A differential pulsevoltammetry (DPV) method for the determination of picoplatin was proposed based on the GR- MWNTs/GCE. Under the optimal conditions, the proposed method exhibited linear ranges from-6 -1 -5 -1 -7 -12.1310 mol L to 3.4610 mol L . It can be used to detect as low as 2.1010 mol L ofpicoplatin with a recovery of 96.0~99.0% and RSD ranges of 0.73%~1.60%. The proposed methodwas used for the determination of picoplatin in this work.