Voltammetric Determination of Amoxicillin at the Electrochemical Sensor Ferrocenedicarboxylic Acid Multi Wall Carbon Nanotubes Paste Electrode

摘要

A sensitive and selective electrochemical method for the determination of amoxicillin (AMX) wasdeveloped using a ferrocenedicarboxylic acid modified carbon natubes paste electrode (FDCCNTPE).The modified electrode exhibited good electrocatalytic activity for electrochemical oxidation of-5 2 - amoxicillin at the pH of 10.5 phosphate buffer solution. The diffusion coefficient (D= 4.62 10 cm s 1 ), and the kinetic parameter such as the electron transfer coefficient (= 0.494) of AMX at the surfaceof FDCCNTPE were determined using electrochemical approaches. Under the optimized conditions,the electrocatalytic oxidation peak current of amoxicillin showed two linear dynamic ranges with a-1detection limit of 8.7 nmol L amoxicillin. The linear calibration ranges was in the range of 0.03-0.35-1 -1 mol L and 0.50-32.70 mol L amoxicillin using square wave voltammetric method. Finally, thismodified electrode was also examined for the determination of amoxicillin in real samples such asdrug and urine.