Replication of association of nine susceptibility loci with Graves’ disease in the Chinese Han population

摘要

This study is to evaluate the association of 9 single nucleotide polymorphisms (SNPs) with Graves’ disease (GD) in different homogenous samples of the Chinese Han population. A total of 2,865 unrelated individuals were enrolled from Linyi City, Shandong Province, China, including 1,139 patients of GD and 1,726 controls. All 9 SNPs showed significant associations with GD (emP/em < 1.3×10sup-4/sup, Bonferroni corrected emPsubc/sub/em < 0.001). The most significant association was detected at rs2281388 at the emHLA-DPB1/em locus (emP/em=1.3×10sup-21/sup; OR=1.62, 95% CI: 1.47-1.79). After adjusting for gender and age, 7 SNPs remained significantly associated with GD (emP/em < 3.4×10sup-4/sup, emPsubc/sub/em < 0.003). The risk of GD caused by any of these SNPs was not significantly different between female and male participants (Psubhet/sub > 0.15). Four SNPs located in emMHC/em regions were significantly associated with GD in different ages (emP/em < 8.4×10sup-4/sup, emPsubc/sub/em < 0.04). The risks of any SNP leading to the development of GD did not differ significantly in different ages (emP_trend/em > 0.02, emPsubc/sub/em > 0.18). The rs6457617 at the emHLA-DR-DQ/em locus was significantly correlated with gender in GD patients (emP/em=0.004, emPsubc/sub/em=0.04). No significant correlation was found between any SNP and age of diagnosis in GD patients (emP/em > 0.02, emPsubc/sub/em > 0.17). The 9 previously identified SNPs are associated with GD in the Chinese Han population. And, gender and age may not influence the associations between the 9 SNPs and GD.