Comparison of Sleep Quality Using Pittsburgh Sleep Quality Index (PSQI) on Patient with Anxiety Disorders Treated Using Long-Term and Short-Term Benzodiazepine Therapy

摘要

Benzodiazepines are widely used and become the primary choice for sleep disorders. This study aims to determine the comparison of sleep quality in patients with anxiety disorders using long-term and short-term benzodiazepines. This study was a cross-sectional observational study conducted on anxiety disorder patients who undertake medical check-up in Hasanuddin University Hospital and its network. The study was conducted from October to November 2017. The subject of the study was 94 divided into two groups, the group of 64 subjects were taking benzodiazepine alprazolam, and the group of 30 subjects were taking clobazam. From each group, the quality of sleep of subjects taking alprazolam and clobazam for long-term (>6 months) and short-term (≤6 months) would be assessed. Data were analyzed statistically by using Mann-Whitney and Wilcoxon test. The results showed that sleep quality which was measured by using an Indonesian version of The Pittsburgh Sleep Quality Index (PSQI) to the group of subjects taking long-term alprazolam i.e >6 months (mean: 9.343.39) and taking short-term alprazolam i.e ≤6 month (mean: 4.061.07), had a very significant difference (p 6 months (mean: 4.401.50) and those taking short-term clobazam i.e ≤6 months (mean: 3.33±0.72) had significant differences (p= 0.021). This study concludes that sleep quality in subjects with anxiety disorders using long-term benzodiazepine therapy either on alprazolam or clobazam was worse than subjects who use short-term benzodiazepine therapy.