Anxiolytic Effects of Senna singueana in Mice after Exposure to Chronic Restraint-Stress

摘要

Senna singueana (Cesalpiniaceae) root is traditional medicine used in many countries in Africa to treat epilepsy, agitation, malaria. In the present study, the anxiolytic effect of decoction of S. singueana root was evaluated on chronic stress induced biochemical and psychological changes in mice. Chronic stress was induced by chronic restraint stress method and the effects of S. singueana at the doses of (40, 100, 200, 400 mg/kg) was evaluated on levels of plasma serotonim and corticosterone after the final exposure to chronic stress the elevated plus-maze tests were performed to measure the level of anxiety. These results suggest that S. singueana shows the ameliorating effects on chronic restraint stress by modulating the activity of the serum levels of corticosterone and serotonin.