Effect of total aqueous stem bark extract of spondias mombin l. on some biochemical and anthropometric parameters in wistar albino rats

摘要

Spondias mombinL. (Anacardiaceae) is a medicinal plant used in the treatment of digestive disorders in C.te d'Ivoire. In order to verify its safety, the total aqueous stem bark extract is administered orally daily for 28 days, three groups of albino Wistar rats at 250, 500 and 1000 mg / kg body weight. The control group received distilled water. Measurements are made to determine the daily amount of food and the volume of water consumed, the body mass is evaluated each week. A blood sample is taken once a week to determine the effect of the extract on blood biochemical parameters. Repeated administration of total aqueous stem bark extract of Spondiasmombinhas not deeply disturbed consumption of food and water in all treated rats. Weight gain was observed in all rats throughout the study. Blood biochemical parameters such as glucose, cholesterol and Glutamate Oxaloacetate Transaminase (SGOT) were not changed in rats treated compared to the control group. In contrast, Glutamate-Pyruvate Transaminase (SGPT), creatinine and urea to a lesser degree, increased particularly in patients treated with doses of 500 and 1000 mg / kg body weight to the fourth week of treatment. These studies revealed that the total aqueous stem bark extract of Spondiasmombinmay be slightly toxic to the liver and kidney when taken in high doses prolonged way