Anti-hyperglycemic effect of aqueous extract of Rosa canina L. fruit in type 2 diabetic patients A randomized double- blind placebo controlled clinical trial

摘要

Rosa canina L. (rose hip) have been traditionally used to treat diabetes in Iran. But yet, no scientific human study hasdetermined its efficacy in diabetic patients. This study was conducted to evaluate the effect of aqueous extract of R.canina fruiton blood glucose in type 2 diabetic patients. Forty eight type2 diabetes patients aged 35-60 years with fasting blood glucoselevels between 130 mg/dl and 250 mg/dl and HbA1c more than7% despite using conventional oral hypoglycemic drugs tookthe capsule of R. canina fruit (750 mg/BD) and toast powder capsule (placebo) randomly for 3 months. Fasting blood glucose(FBG) and postprandial blood glucose (PBG) were assessed as primary outcome measures. Glycosylated hemoglobin (HbA1c),lipid profile, hepatic and renal function were assessed as secondary outcome measures. They were compared with baseline inboth groups with paired t-test in SPSS v: 17. Twenty five patients in Rosa canina group and 23 in control group with mean(±SD) of age 56.3(9.2) completed the study. The FBG level decreased significantly in R. canina group after 3 months compareto baseline (mean= 25.6, 95% CI= 11.5-39.5). Changes of PPG and HbA1c in R. canina group were not significantly more thanplacebo group. No serious side effects were reported in both groups during the study. This pilot study did not show thelowering effect of aqueous extract of R. canina in type 2 diabetic patients. Conducting other clinical studies with larger dose ofthis herb is suggested for precisely conclusion about the efficacy of this herb in diabetic patients.