A REVIEW: FAST DISSOLVING DRUG DELIVERY SYSTEM: CURRENT DEVELOPMENTS IN NOVEL SYSTEM DESIGN AND TECHNOLOGY

摘要

The oral route of drug administration is the most important method for administering drugs for systemic effects. The oral drug delivery market, in particular, remains the largest segment of the overall drug delivery market, presently valued at $49 billion, and growing at a rate of 10% each year 1 . Except in certain cases the parenteral route is not routinely used for self administration, e.g. insulin. The topical route of administration has only recently been employed to deliver drugs to the body for systemic effects. So therefore fast dissolving drug delivery has received ever-increasing demand during last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the saliva without need of water with good mouth feel property. ??The popularity and usefulness of the formulation resulted in development of several FDT technologies. Fast- or mouth dissolving tablets have been formulated for pediatric, geriatric, and bedridden patients and for active patients who are busy and traveling and may not have access to water. This review explains the recent advances in fast dissolving drug delivery systems with special focus on its new breakthrough in various formulation aspects resulted in development of several FDT technologies