VALACYCLOVIR: DEVELOPMENT, TREATMENT AND PHARMACOKINETICS

摘要

Acyclovir a specific and selective inhibitor of herpes virus has been used safely andeffectively. The bioavailability of the drug is low results in poor absorption of drug. Valacycloviris the L- valyl ester prodrug of Acyclovir. It is used in the treatment of Herpes simplex virus andVaricella zoster virus. After oral administration it is rapidly converted to acyclovir in the Gastrointestinal tract and liver, which increases the bioavailability of acyclovir three to five times thatof acyclovir alone.