STUDIES ON ANTIMICROBIAL ACTIVITY OF ACTINOMYCETES AGAINST MDR WOUND BACTERIAL ISOLATES

摘要

A total of five different actinomycete isolates were recovered from mine soil samples collected fromSalem, Tamilnadu. These were then assessed for their antibacterial activity against five multidrug resistancebacterial wound isolates. All five isolates of actinomycete exhibited antagonistic activity. The zone of inhibitionranged between 11-25 mm.Among the 5 isolates of actinomycetes A5 isolate has highest antibacterial activityagainst S.aureus andE.coli. Out of five bacterial isolates Pseudomonas aeruginosa was highly suppressed byactinomycetes followed by E.coli. The maximum antibacterial activity was observed on 14thday incubation. Theresult of primary screening reveals that most of the active actinomycetes isolates were active against gram positivebacteria (S.aureus) than gram negative bacteria. The antibiotic profile of these isolates underlined their potential asa source of novel antibiotics