Two Approaches to Control of Fed-batch Fermentation Process

摘要

L-lysine is one of the irreplaceable aminoacids whose content in the animal protein is relatively high in comparison to plants, where the content is relatively low. The insufficiently L-lysine quantity in the fodders reduces the biological value of the fodder doses, reduces the weight increase and the further productiveness of the agricultural animals, it increases the fodder quantity, used for a kilogram growth and decreases the product quantity of animal origin. The most effective and cheapest method for the L-lysine biosynthesis (in biological active form) is the microbiological method via a direct fermentation. In this paper it is used an optimization method at the L-lysine production from strain Brevibacterium flavum 22LD - Neuro-dynamic programming. For receiving a feedback and robustness of the optimal control profile the Model predictive control of the L-lysine production is developed