The input-output effects of science and technology are critical for the level of technological development while what was often overlooked is that the overall consistency of each individual input. In this study the large and medium-sized industrial enterprises? science and technology investments was the starting point, we analyzed data of all districts? inputs and outputs in Shanghai since 2003 by using the Grey correlation analysis and Grounded theory. As a conclusion according to evaluating the degree of consistency of each district with the overall scientific and technological development in Shanghai, some relevant policy recommendations were listed as follows: (1) To establish large-sized high-tech industrial parks, for instance, science and technology parks, high-tech development zone, etc. which can effectively promote the local science and technology development; (2) To adjust industrial layout which is the key issue for input-output effectiveness of science and technology; (3) To strengthen the constructions of traffic and road which contributes to the urban-rural integration.
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