Pre-exchange transfusion administration of albumin: An overlooked adjunct in the treatment of severe neonatal jaundice?

摘要

IMoslehi(1) report that albumin given prior to exchange transfusion in jaundiced but healthy term newborns is associated with significantly n this issue of Indian Pediatrics, Shahian andlower post-procedure total serum unconjugatedbilirubin levels (TSB) and a reduced need for furthertreatment. Unfortunately, the evidence presenteddoes not support routine administration of albuminprior to exchange transfusion because the actualamounts of bilirubin removed by the procedure arenot documented. The bilirubin removed by theprocedure is readily obtained by measuring thevolume and bilirubin content of the blood discardedduring the procedure(2-4). Without these criticaldata, the study does not prove causation (i.e. thatalbumin administration was the cause of thedifference in outcome).