Somatostatin receptor positron emission tomography/computed tomography (PET/CT) in the evaluation of opsoclonus-myoclonus ataxia syndrome

摘要

Opsoclonus-myoclonus ataxia (OMA) syndrome is the most common paraneoplastic neurological syndrome of childhood, associated with occult neuroblastoma in 20%-50% of all cases. OMA is the initial presentation of neuroblastoma in 1%-3% of children. Conventional radiological imaging approaches include chest radiography and abdominal computed tomography (CT). Nuclear medicine techniques, in form of 123I/131I-metaiodobenzylguanidine (MIBG) scintigraphy have been incorporated in various diagnostic algorithms for evaluation of OMA. We describe use of somatostatin receptor PET/CT with 68Gallium- DOTA-DPhe1, Tyr3-octreotate (DOTATATE) in diagnosis of neuroblastoma in two cases of OMA.Keywords: Occult neuroblastoma, opsoclonus-myoclonus ataxia, somatostatin receptor PET/CT, 68Gallium DOTATATE