Immune reconstitution inflammatory syndrome after initiation of highly active anti-retroviral therapy in HIV/AIDS

摘要

In the infectious category, most frequently reported cases are - Mycobacterium tuberculosis (TB), cryptococcal meningitis, varicella zoster, herpesviruses, CMV, Pneumocytis (carinii) jiroveci pneumonia (PCP), hepatitis B and C etc. [1] Other conditions i.e. Mycobacterium avium complex(MAC), latent cryptococcal infection are also reported. The non infectious causes include rheumatoid arthritis and other auto immune diseases. [2]Besides a direct reaction to infectious and non infectious agents, a third group of patients reacts as a result of their host genetic susceptibility. Forexample, they carry specific HLA alleles like HLA class II, interleukin -1 (IL-1), IL-6, TNF-α develop IRIS to specific antigens. [3].