Yellapragada SubbaRow – The unsung Indian biochemist behind methotrexate and other drugs

摘要

“You have probably never heard of Dr. Yellapragada SubbaRow. Yet because he lived you may be alive and well today, because he lived youmay live longer.” wrote Doron K. Antrim in “Argozy,” an American magazine in 1950s.[1] Methotrexate has been proved to be one of the bestUnited States Food and Drug administration-approved drugs for dermatologists in India, as it is cheap and effective in managing cases of psoriasisand Sezary syndrome along with many off label uses.[2] Most of the clinicians in an overpopulated country like India have prescribedmethotrexate, while being ignorant of the brain behind the molecule.