The novel DYRK1A inhibitor KD03 alters neuroinflammation in BV2 microglial cells, wild-type, and Alzheimer's transgenic mice

摘要

Activation of astrocytic mu-opioid receptor causes conditioned place preference Background: Neuroinflammation is correlated with neurode- generative diseases, such as Alzheimer’s disease (AD), and thus neuroinflammatory responses regulation is considered as a poten- tial therapeutic strategy for neuroinflammation-related and/or neurodegenerative diseases.