Mechanistic pathway involved in hypobaric hypoxia inducing cognitive impairment and neurodegeneration

摘要

Mechanistic pathway involved in hypobaric hypoxia inducing cognitive impairment and neurodegeneration As we ascent to high altitude, partial pressure of oxygen reduces, causing insufficient supply of oxygen from air to body tissues which leads to oxidative stress and this reduces the availability of oxy- gen to different body parts. This pathophysiological condition is known as hypobaric hypoxia. Brain is predominantly suscepti- ble to oxidative stress during hypobaric hypoxia, and therefore undergoes neurodegeneration due to energy crisis predominantly in hippocampus which causes memory dysfunction is reported in neurodegenerative disorders in humans but the mechanism is still unknown. Hypobaric hypoxia is an interest for researchers because the accidents occur with military personnel, mountain res- cue teams and aviators since its neurological effects impair their mental performance. The present study is to delineate the mech- anistic pathway involved in hypobaric hypoxia causing neuronal loss and neuroinflammation in male Balb/C mice.