Gait ignition failure in JNPL3 human Tau-mutant mice

摘要

EF. Follow-up results of this longitudinal study are important to clarify the trajectory of the relationship between sleep, hyperactivity and EF. Encoding of contextual fear memory in the hippocampal-amygdala engram cell pathway In contextual fear conditioning, experimental subjects learn to associate a neutral context with an aversive stimulus and dis- play fear responses to a context that predicts danger. Although the hippocampal-amygdala pathway has been implicated in the retrieval of contextual fear memory, the mechanism by which fear memory is encoded in this circuit has not been investi- gated. Here, we show that activity in the ventral CA1 (vCA1) hippocampal projections to the basal amygdala (BA), paired with aversive stimuli, is both necessary and sufficient to generate condi- tioned fear memory. Contextual fear conditioning induced selective strengthening of the vCA1-BA engram cell pathway, which was prevented under anisomycin-induced retrograde amnesia. More- over, BA engram cells preferentially received monosynaptic inputs from vCA1 engram cells, whose activity was required for contex- tual fear learning. Our study suggests that strengthening of the vCA1-BA engram cell pathway plays pivotal roles in adaptive fear to a relevant context.