Neuro-glia interaction in pain circuit dynamics following peripheral nerve injury

摘要

OPCs, mouse OPCs have been proven much more difficult to isolate and differentiate. Given the many transgenic and knockout mouse models that are available and those that are being developed, it is useful to develop a simple and effective method to culture oligodendrocytes from mouse tissues. In this study, we have established a method to differentiate oligodendrocytes from mouse OPCs. In oligodendrocyte monoculture and coculture with neurons, we found that microtubules play an important part in the differentiation and myelination of oligodendrocyte.